Despite the importance of this cancer prevention program, a number of long-standing questions about replicative senescence remained unanswered. It wasn't clear which DNA damage signaling pathway ...

Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, ...

“Overall, this study further demonstrates the utility of high-content morphological analysis as a tool for the identification of senescent cells.” “Overall, this study further demonstrates the utility ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

Senescence, aging, and age-related diseases represent complex biological phenomena with significant impacts on human health, and metabolism and metabolomics play pivotal roles in understanding their ...