Phosphorylation, a pivotal post‐translational modification, regulates a wide array of cellular processes by the covalent attachment of phosphate groups to proteins. This modification, largely executed ...
BACKGROUND: Oscillatory shear stress (OSS), resulting from disturbed blood flow, is implicated in atherosclerotic plaque formation by incompletely understood mechanisms. This study aims to elucidate ...
Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...
Researchers uncovered how polyamines influence cell fate by altering protein phosphorylation and alternative splicing. The ...
Conventional small-molecule drugs for reducing pTau include phosphatase activators of PP2A, and kinase inhibitors of GSK3β, CDK5, etc., as well as active or passive immunotherapies targeting pTau.
The partnership is supported by the Michael J. Fox Foundation, which seeks to better understand aSyn protein's role in Parkinson's disease.
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