Until recently, protein–protein interactions (PPIs) were seen to present contact surfaces too broad and featureless to give newly developed PPI-modulating drugs much purchase. Developers of such drugs ...

Researchers capture first-of-its-kind video of dynein–Lis1 protein interaction, supporting future drug development for neurological disorders. Our cells rely on microscopic highways and specialized ...

Scientists have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat with medication. The computational tool is ...

The Light-Activated BioID technique invented by biomedical engineers at UC Davis could enable studies of how proteins interact with each other inside cells. Biomedical engineers at UC Davis have come ...

Learn how experts in various techniques, such as surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC), measure protein–protein interactions (PPIs) for therapeutic development.

Many biological functions are facilitated by the interaction between two or more proteins. Studying and understanding protein-protein interactions is thus essential for understanding physiological ...

Proteins function through interactions with other proteins or peptides, a complex process that is still not fully understood. Current research focuses on how amino acid residues interact in ...

Down syndrome, a congenital disorder stemming from abnormal cell division and differentiation, is most common in newborns fated to neurodevelopmental delays and other health complications. The genetic ...

The pros and cons of moonlighting—taking up an extra job in addition to full-time employment—are hotly debated. But in biology, moonlighting is not uncommon, as individual proteins often perform ...

Cornell researchers have discovered a new way cells regulate how they respond to stress, identifying an interaction between two proteins that helps keep a critical cellular recycling system in balance ...