In gene therapy, promoters act as vital “on/off” switches, dictating whether a therapeutic gene is active and to what extent. While delivery vehicles such as adeno-associated viruses (AAVs) can bring ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a number of ...

In this study, researchers analyzed large ASD whole genome sequencing data and found that promoter de novo mutations in TADs containing ASD genes were specifically associated with the disease.

Inducible promoters provide remarkable utility when sustained transgene expression compromises plant development or agronomic ...