Formulation scientists are behind the conversion of active pharmaceutical ingredients (API) into stable, bioavailable, and commercially viable dosage forms, rarely a simple process. Image Credit: ...

In the last 10 years, there has been significant development in computer simulation of pharmaceutical materials, processes and product performance. Gradually, more mechanistically based models are ...

Expertise in CMC (chemistry, manufacturing, and control) ensures the appropriate manufacture of a pharmaceutical or biologic by coordinating material characterization, formulation development, and ...

Researchers at the University of Toronto say they have successfully tested the use of machine learning models to guide the design of long-acting injectable drug formulations. The potential for machine ...

Drug development is an unforgiving business. Discovering a novel molecule is difficult enough, but then it can take years of preclinical studies and molecular tweaking to mitigate a drug’s toxicity, ...

Suzanne Jansen, MSc, PharmD, ICON, says early-phase clinical success depends on flexible, simple formulations that support wide dose ranges, matching placebos, and robust stability. Formulations are ...

To optimize the final formulation for a drug, it must meet many criteria beyond producing a safe and effective product. For example, it must be stable and amenable to various manufacturing steps, such ...

Scientists have successfully tested the use of machine learning models to guide the design of long-acting injectable drug formulations. The potential for machine learning algorithms to accelerate drug ...

Non-invasive delivery systems, like needle-free nasal sprays, improve patient adherence by addressing psychological barriers and offering logistical advantages such as extended shelf life and ...

Spray-dried protein microparticles without MoNi surfactant form paste-like materials (left), whereas those spray dried with MoNi surfactant form injectable suspensions that flow like liquids (right).