Symproic significantly improved bowel function and frequency of spontaneous bowel movements in patients receiving opioids compared to placebo. The study highlighted a 47.6% difference in bowel ...

Opioids can cause opioid-induced constipation by slowing down digestion and reducing fluid in the intestines. NSAIDs like ibuprofen can irritate the stomach lining and slow digestion, leading to ...

Shionogi today announced pivotal phase III study (COMPOSE I) results showing that once-daily treatment with naldemedine significantly improved opioid-induced constipation (OIC) compared to placebo in ...

PALM SPRINGS, California — A peripherally acting oral μ-opioid receptor antagonist is superior to placebo in treating opioid-induced constipation (OIC) and doesn't reduce the analgesic effect of ...

May 12, 2009 (San Diego, California) — Constipation is a well-known adverse effect of opioid analgesics but often goes undiagnosed because patients can be reluctant to talk about it, experts warn.

Tsukuba, Japan—Pain relief for patients with cancer is crucial, and opioids, such as morphine, play a vital role. However, constipation, which negatively affects the patient's quality of life, is a ...

The Food and Drug Administration recently approved the tablet form of Relistor to treat opioid-induced constipation. Relistor, produced by Tarrytown, N.Y.-based Progenics Pharmaceuticals, was ...