BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...
Ibuprofen is a household name – the go-to remedy for everything from headaches to period pain. But recent research suggests ...
Antman notes that despite initial claims of greater GI safety for this class of NSAID, COX-2 is in fact needed for GI mucosal protection; used alone, a COX-2 inhibitor can damage the mucosa, and the ...
Ibuprofen may be doing more than easing aches and pains—it could also help reduce the risk of some cancers. Studies have ...
The discovery of cyclooxygenase (COX) isoforms, COX-1 and COX-2, in the early 1990s helped explain how non-steroidal anti-inflammatory drugs (NSAIDs) work and led to specific agents with fewer ...
Ibuprofen’s anti-inflammatory action may influence cancer risk, but evidence remains complex and routine use for prevention is not advised. Ibuprofen is one of the most widely used pain relievers, ...
NEW YORK (Reuters Health) - Although all of the common strategies protect the upper gastrointestinal tract from the complications of nonsteroidal anti-inflammatory drugs (NSAIDs), popular ...
Aspirin was introduced into clinical medicine in 1899 and its anti-inflammatory, analgesic and antipyretic properties were accompanied by the onset of gastrointestinal and renal toxicity. Over the ...
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