When a salamander loses a leg, it grows back. When a human loses a finger, scar tissue fills the gap. The difference has ...

Three-dimensional image of a developing limb bud generated using LimbLab. It shows where key genes are active during early limb formation. Sox9 (magenta) marks the cells that will become cartilage and ...

Polydactyly, the presence of extra digits, is one of the most common congenital malformations of the limb. Recent genetic studies have significantly advanced our understanding of limb development by ...

In a new study published in Genes & Development, research led by Dr. Lila Allou at the MRC Laboratory of Medical Sciences (LMS) in London and Professor Stefan Mundlos at the Max Planck Institute for ...

This study is reported by Jia-Tang Li’s group from the Chengdu Institute of Biology, Chinese Academy of Sciences. The development of limbs is significant for the origin and evolution of tetrapods, ...

A new study gives insight into how limb development evolved in vertebrates. The findings identify a gene that plays a central role in the evolution of limb development in vertebrates. By manipulating ...