Drug promiscuity can also be evaluated from the reverse perspective, focusing instead on the ability of a single therapeutic agent to interact with multiple protein targets. The most comprehensive ...
Ion channels are transmembrane proteins specifically involved with the transport of inorganic ions like Na+, K+, Ca2+, or Cl-. Ion channels are “gated”, i.e. they open in response to a specific ...
This is a preview. Log in through your library . Abstract The current understanding about ethanol effects on the ligand-gated ion channel (LGIC) superfamily has been restricted to identify potential ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 24 (June 16, 2020), pp. 13437-13446 (10 pages) Pentameric ligand-gated ion channels (pLGICs) are ...
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