Altered intestinal barrier function is postulated to be a central predisposing factor to intestinal diseases, including inflammatory bowel diseases and food allergies. However, the mechanisms involved ...

The colonic mucosal barrier is essential for maintaining digestive health, protecting against pathogens, and preventing inflammation. The Notch signaling pathway is implicated in these processes, as ...

Radhakrishna Rao, PhD, vice-chair and professor in the Department of Physiology at the University of Tennessee Health Science Center (UTHSC), has received two large national awards totaling $5 million ...

Gut health has been shown to be central to the body’s overall health, impacting the immune system and the gut-brain axis. The gut barrier plays a key role in maintaining overall gut health, as it ...

An international research team led by scientists from Bern and Charité - Universitätsmedizin Berlin has identified a previously unknown function of the intestinal nervous system. The study reveals ...

From Ayurveda to the teachings of Hippocrates, medicine's earliest traditions advanced a belief that the gut was the foundation of all health and disease. It wasn't until recently, however, that ...

Dr. Umapathy Sundaram, known as Uma to colleagues, directs research efforts that translate molecular discoveries into ...

Western diets that are high in sugars, fats, and processed foods have been linked to a wide variety of health ailments. Now, researchers have determined that Western diets can also disrupt the crucial ...

Background Both host and microbe metabolism of tryptophan (Trp) is altered in diabetes; however, the molecular mechanisms are ...

The intestinal mucosa absorbs nutrients, water, and electrolytes in a controlled manner–while simultaneously keeping out toxins, allergens, and some bacteria. When this barrier is damaged, it is ...