Scientists manufacture many biotherapeutic products in immortalized cell lines, most commonly HEK293. Residual HEK293 DNA in biotherapeutic candidates can harbor tumorigenic or retroviral sequences ...

A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive ...

The second tool is the CRISPR-Cas9 system, which allows easy and precise editing of any region of the genome. When it comes to traditional immortalized cell lines, such as HeLa or HEK293, cutting with ...

Cell culture is a fundamental technique in biotechnology and life sciences that involves growing and maintaining living cells outside their natural environment, typically in a controlled laboratory ...

Researchers often struggle to select which cells to utilize in their research and when to employ them. Cell lines, dissociated tumor cells, and primary cells all have their place in research. While ...