Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Researchers compared three different drug delivery models based on ionic liquids. Scientists have developed a powerful API-IL concept to access structural diversity and dual-action pharmaceuticals.

Using an X-ray free-electron laser and time-resolved X-ray solution scattering, researchers have watched, on a femtosecond timescale, the detailed steps that occur when covalent bonds form in solution ...

A research group has successfully demonstrated that carbon-carbon (C-C) covalent bonds expand and contract flexibly in response to light and heat. This unexpected flexibility of C-C bonds could confer ...

A research team from Hokkaido University has confirmed a century-old theory by discovering a stable single-electron covalent bond, known as a sigma bond, between two carbon atoms. This unique bond ...