A computational study focused on the mechanistic pathway of the SpnF-catalyzed cycloaddition reaction leading to Spinosyn A -- tetracyclic natural insecticide produced by the cells of the bacterium ...

The Diels-Alder reaction is a classic transformation that typically marries a diene (with four π electrons) and an alkene (with two π electrons) to form a six-membered ring—it’s known as a [4+2] ...

Creating rings, or carbocycles, with a six-carbon skeleton is an elementary exercise for synthetic organic chemists. Ask one how it’s done, and the chemist will inevitably point to the stalwart ...

Until recently it was assumed that cycloaddition reactions (also widely known as the Diels-Alder reactions) do not occur in nature, since corresponding enzymes were never discovered. However, it was ...