Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Researchers discover unexpected patterns in mutation risks across individuals, uncovering 13 distinct genomic patterns. The study provides crucial insights into cancer evolution, identifying the genes ...

The gene p53 acts as a tumor suppressor and is often called the guardian of the genome. This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading to ...

Any detectable mitochondrial heteroplasmy was associated with increased incident CLL risk after multivariable adjustment in UK Biobank (HR 1.5), supporting mtDNA variation as a nontraditional risk ...

According to a study from MIT, NDMA, a carcinogen that has been found in some drugs and drinking water contaminated by chemical plants, may have a much more severe impact on children than adults.