Tuberous sclerosis complex (TSC) afflicts as many as two million people around the world, affecting multiple organs, including lungs, brain, skin, and kidneys. In about 80 percent of cases, it causes ...

The disease leads to the progressive growth of fluid-filled cysts in the kidneys, often resulting in kidney failure and other ...

Tuberous sclerosis complex and von Hippel–Lindau disease are distinct autosomal dominant tumor suppressor syndromes that can exhibit similar renal phenotypes and seem to share some signaling pathway ...

Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic renal disease, primarily caused by germline mutation of PKD1 or PKD2, leading to end-stage renal disease. The Hippo ...

Cysts can form in the kidney for many reasons, and most such cysts are benign (non-cancerous). However, in some instances a cyst may become enlarged to the point that it causes pain, obstructs the ...

Mayo Clinic researchers have developed a promising gene-editing therapy that directly corrects a genetic mutation responsible ...

Birt-Hogg-Dubé syndrome (BHDS) is a genetic disorder that increases the risk of developing benign skin cancers, polycystic kidney disease (PKD), lung cysts, and many types of kidney cancers. PKD is ...

Often kidney cyst and kidney tumour induce the same kind of fear. But according to Dr. Sumit Bansal, consultant – urology, Manipal Hospital Dwarka, New Delhi, they are distinctly different. In an ...

A 46-year-old man who recently moved to the area was referred to the nephrology clinic for kidney cysts. He was found to have multiple cysts in the left kidney at age 27 for which he was referred to ...