(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Bile acid metabolism disorders encompass a range of rare, yet clinically significant, genetic conditions that disrupt the normal synthesis and regulation of bile acids by the liver. These conditions, ...

Bile acids, synthesised from cholesterol in the liver, are central to lipid digestion but also serve as signalling molecules that regulate metabolism, inflammation and cellular homeostasis. In ...

Liver is the major organ for metabolism of sulfur amino acids (methionine, cysteine, taurine) and expresses high levels of sulfur amino acid synthesis and metabolising enzymes. Dietary intake, ...

A study published in the journal Cell Metabolism finds that hyodeoxycholic acid alleviates non-alcoholic fatty liver disease by modulating the gut-liver axis. Study: Hyodeoxycholic acid alleviates non ...

A study published in the journal Protein & Cell details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid ...

Primary biliary cholangitis (PBC) is a rare chronic autoimmune cholangiopathy that mainly affects middle-aged women, ...

In a recent study published in Nutrients, scientists provide a detailed overview on age-related alterations in lipid metabolism and its association with age-related chronic diseases. Study: The Roles ...

New research links altered bile acids to chronic kidney disease progression, highlighting potential metabolic pathways ...