Researchers at Brown University and the Marine Biological Laboratory at Woods Hole, Mass., have found a physical connection between the herpes simplex virus and amyloid precursor protein, a protein ...
β-Secretase (BACE, Asp-2) is a transmembrane aspartic proteinase responsible for cleaving the amyloid precursor protein (APP) to generate the soluble ectodomain ...
Brain cells are constantly swallowing material from the fluid that surrounds them—signaling molecules, nutrients, even pieces of their own surfaces—in a process known as endocytosis that is essential ...
A new study strengthens the idea that reelin, an extracellular matrix protein essential for brain development, works, at least in part, by binding amyloid precursor protein (APP). In the June 10 ...
Amyloid fibrils are infamous for the role they play in serious neurological diseases in humans, such as Parkinson's or Alzheimer's. One trigger for Alzheimer's disease is the misfolding and ...
Amyloid plaques are one of the hallmarks of Alzheimer's disease and were first described almost one hundred years ago by Alois Alzheimer. Today, however, their formation is still something of a ...
(A, B) ALP staining and activity detection were performed after treating cells with APPswe or BMP2 for 5 days or 7 days. (C, D) ARS staining and semiquantitative analysis were used to detect calcium ...
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