Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced "mew-opioid") receptors. What they didn't know - until now - was ...

Visual Abstract. Whole-body [11C] carfentanil PET imaging at baseline (left side of panel) and then following naloxone (middle panel) shows μ-opioid receptor (MOR) in the brain (color) and throughout ...

Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...

A novel compound strongly improves the efficacy of naloxone, the substance used to reverse overdoses of morphine, fentanyl and other opioid drugs. When administered to mice along with naloxone, it is ...

Opioid medications offer people relief from debilitating pain, but these drugs are associated with the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

Naloxone (also known as Narcan, the commonly used drug to treat narcotic overdoses) has greater binding to opioid receptors in women's brains than in men's brains, according to new research published ...

Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...